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《医学前沿(英文)》 2017年 第11卷 第2期 页码 266-276 doi: 10.1007/s11684-017-0530-y
Childhood obesity and obesity-related metabolic complications are induced by a high-fat postnatal diet. The lack of a suitable animal model, however, remains a considerable challenge in obesity studies. In the current study, we provided high-fat diet (HFD) to dams during lactation and to pups after weaning. We also developed a novel model of C57BL/6J mouse pups with HFD-induced postnatal obesity. Results showed that feeding with HFD induces fat deposition and obesity in pups. Furthermore, HFD more potently increased the body weight (BW) of male than female pups. HFD-fed female pups were obese, underwent precocious puberty, and showed increased kisspeptin expression in the hypothalamus. However, parental obesity and precocious puberty exerted no synergistic effects on the HFD-induced postnatal weight gain and puberty onset of the pups. Interestingly, some HFD-fed litters with normal BW also exhibited precocious puberty. This finding suggested that diet composition but not BW triggers puberty onset. Our model suggests good construction validity of obesity and precocious puberty. Furthermore, our model can also be used to explore the mutual interactions between diet–induced postnatal childhood obesity and puberty.
关键词: postnatal HFD feeding obesity kisspeptin HPG axis precocious puberty
Five-axis rough machining for impellers
Ruolong QI, Weijun LIU, Hongyou BIAN, Lun LI
《机械工程前沿(英文)》 2009年 第4卷 第1期 页码 71-76 doi: 10.1007/s11465-009-0010-4
关键词: five-axis impeller tool-path planning flank milling ruled surface
Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar
Min WANG, Jianzhong HU, Tao ZAN
《机械工程前沿(英文)》 2010年 第5卷 第4期 页码 431-437 doi: 10.1007/s11465-010-0110-1
关键词: error modeling error separation telescoping double ball bar five-axis numerical control (NC) machining tool
Optimization model for rotor blades of horizontal axis wind turbines
LIU Xiong, CHEN Yan, YE Zhiquan
《机械工程前沿(英文)》 2007年 第2卷 第4期 页码 483-488 doi: 10.1007/s11465-007-0084-9
关键词: population extended algorithm developed optimization accurate
杜金名
《中国工程科学》 2005年 第7卷 第1期 页码 65-68
气体静压轴承广泛应用于航空、航天、精密电子工业中。三轴转台是高精度的测试设备,用来对惯性系统和惯性元件进行检定、标定以及建立相应的误差模型,它的测试精度直接影响航空、航天等飞行器的控制和导航。转台的检测精度与回转轴的回转精度有密切关系。多孔质气体静压轴承同其他节流形式的轴承相比具有很高的承载能力、静态刚度以及很好的阻尼效应。文章对多孔质气体静压轴承进行了理论分析,并同气体静压小孔节流轴承的静态性能进行了比较,结果表明,此类轴承的承载能力明显优于小孔节流轴承。
Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower
Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG
《能源前沿(英文)》 2022年 第16卷 第4期 页码 683-696 doi: 10.1007/s11708-020-0689-9
关键词: vertical axis water turbine eye-shaped vertical water baffle pico hydropower
Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL
《机械工程前沿(英文)》 2021年 第16卷 第2期 页码 298-314 doi: 10.1007/s11465-020-0621-3
关键词: workpiece setup parameter five-axis space utilization setup parameters machine tool
Role of the forkhead transcription factor FOXO-FOXM1 axis in cancer and drug resistance
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 376-380 doi: 10.1007/s11684-012-0228-0
The forkhead transcription factors FOXO and FOXM1 have pivotal roles in tumorigenesis and in mediating chemotherapy sensitivity and resistance. Recent research shows that the forkhead transcription factor FOXM1 is a direct transcriptional target repressed by the forkhead protein FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling pathway. Intriguingly, FOXM1 and FOXO3a also compete for binding to the same gene targets, which have a role in chemotherapeutic drug action and sensitivity. An understanding of the role and regulation of the FOXO-FOXM1 axis will impact directly on our knowledge of chemotherapeutic drug action and resistance in patients, and provide new insights into the design of novel therapeutic strategy and reliable biomarkers for prediction of drug sensitivity.
关键词: FOXO3a FOXM1 transcription factor cancer drug resistance tumorigenesis
Estimation of power in low velocity vertical axis wind turbine
Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.
《机械工程前沿(英文)》 2015年 第10卷 第2期 页码 211-218 doi: 10.1007/s11465-015-0338-x
The present work involves in the construction of a vertical axis wind turbine and the determination of power. Various different types of turbine blades are considered and the optimum blade is selected. Mechanical components of the entire setup are built to obtain maximum rotation per minute. The mechanical energy is converted into the electrical energy by coupling coaxially between the shaft and the generator. This setup produces sufficient power for consumption of household purposes which is economic and easily available.
《医学前沿(英文)》 2022年 第16卷 第2期 页码 295-305 doi: 10.1007/s11684-021-0857-2
关键词: chronic heart failure trimethylamine-N-oxide flavin monooxygenase 3 single nucleotide polymorphism
Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia
《医学前沿(英文)》 2022年 第16卷 第3期 页码 442-458 doi: 10.1007/s11684-021-0877-y
关键词: T-cell acute lymphoblastic leukemia HDAC inhibitor chidamide NOTCH1 MYC ubiquitination
CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming
《医学前沿(英文)》 2007年 第1卷 第3期 页码 287-293 doi: 10.1007/s11684-007-0055-x
夏敦柱,周百令,王寿荣
《中国工程科学》 2007年 第9卷 第8期 页码 66-68
介绍了在开环工作状态下硅微z轴谐振陀螺仪由于加工工艺缺陷所导致的误差机理。为减小陀螺仪初始电容差和抑制正交耦合误差,提出了一种闭环控制检测策略。重点分析了其力矩反馈器的电刚度效应并给出其线性数学模型表示式。通过对硅微z轴陀螺仪敏感模态的反馈力与谐振频率的关系分析,间接得出了在敏感方向上电负刚度与力矩器所施电压的内在联系,并在实验上进一步验证电刚度效应。这将为下一步闭环控制方案的设计奠定重要基础。
Atypical pituitary hormone–target tissue axis
《医学前沿(英文)》 2023年 第17卷 第1期 页码 1-17 doi: 10.1007/s11684-022-0973-7
关键词: thyroid-stimulating hormone follicle-stimulating hormone luteinizing hormone adrenocorticotrophic hormone prolactin
Analysis and characterization of wind-solar-constant torque spring hybridized model
Shantanu ACHARYA,Subhadeep BHATTACHARJEE
《能源前沿(英文)》 2014年 第8卷 第3期 页码 279-289 doi: 10.1007/s11708-014-0312-z
关键词: hybrid vertical axis wind turbine Stirling engine solar-thermal energy wind energy constant torque spring
标题 作者 时间 类型 操作
Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty
null
期刊论文
Kinematic error separation on five-axis NC machine tool based on telescoping double ball bar
Min WANG, Jianzhong HU, Tao ZAN
期刊论文
Optimization model for rotor blades of horizontal axis wind turbines
LIU Xiong, CHEN Yan, YE Zhiquan
期刊论文
Performance of vertical axis water turbine with eye-shaped baffle for pico hydropower
Zhuohuan HU, Dongcheng WANG, Wei LU, Jian CHEN, Yuwen ZHANG
期刊论文
Determination of the feasible setup parameters of a workpiece to maximize the utilization of a five-axis
Aqeel AHMED, Muhammad WASIF, Anis FATIMA, Liming WANG, Syed Amir IQBAL
期刊论文
Estimation of power in low velocity vertical axis wind turbine
Sampath S. S.,Sawan SHETTY,Chithirai Pon Selvan M.
期刊论文
FMO3--TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection
期刊论文
Effects of parenteral nutrition with and without GH on the GH/IGF-1 axis after hepatectomy in hepatocellular
CAO Jie, LUO Shimin, LIANG Lijian, LAI Jiaming, CHEN Shanming
期刊论文